Effects of single bolus exposure to propofol on depression-like behavior in a chronic unpredictable mild stress model in mice - PubMed
6 hours ago
- #Propofol
- #Antidepressant
- #GABA
- Propofol shows rapid antidepressant-like effects in mice exposed to chronic unpredictable mild stress (CUMS).
- The study found that propofol (50 mg·kg⁻¹) significantly reduced depression-like behaviors in both male and female mice.
- Propofol increased GABAergic neuron excitability and suppressed glutamatergic activity in the medial prefrontal cortex (mPFC).
- The antidepressant effects of propofol were mediated through GABAA receptor activation and restoration of GABA/glutamate balance.
- Optogenetic activation of GABAergic interneurons enhanced propofol's antidepressant effects, while inhibition attenuated them.
- The study suggests propofol as a potential tool for investigating fast-acting antidepressant mechanisms.