Developing WNT-derived bone anabolic peptides for skeletal aging and fracture by reconstructing thumb and index domains of WNT7B - PubMed
3 hours ago
- #osteoporosis treatment
- #bone anabolic peptide
- #WNT7B
- Researchers reconstructed the thumb and index domains of WNT7B (WNT7BRTID) to develop a bone anabolic peptide using Alphafold and in silico screening.
- WNT7BRTID peptides showed therapeutic potential in aged mice and pig osteoporosis models by improving MSC osteogenic potential and bone regeneration.
- The peptide enhances intrinsic tissue-residual MSC function and osteogenic lineage generation without requiring MSC transplantation to repair critical-sized defects.
- WNT7BRTID activates non-canonical Ca2+-NFAT signaling via RECK/GPR124 for bone anabolic effects, independent of oncogenic canonical Wnt/β-catenin signaling.
- The study suggests WNT7BRTID could serve as a bone anabolic agent to alleviate bone loss in aging and aid fracture repair by promoting MSC function.