Physics-based nucleosome-resolution modeling of epigenetic-driven chromatin domain dynamics - PubMed
4 hours ago
- #Chromatin dynamics
- #Epigenetic modeling
- #Nucleosome resolution
- Physics-based coarse-grained model captures chromatin organization from nucleosome dynamics to phase separation.
- Model incorporates DNA linker length, histone acetylation, linker histone H1, and proteins like BRD4 effects.
- Simulations of 100 kb regions on seconds timescale show chromatin folds into liquid-like epigenetic domains.
- Dynamic domains facilitate transient contacts between distant cis-regulatory regions in embryonic stem cell loci.
- In silico mutations clarify individual epigenetic factors' roles in shaping genomic organization.