Combined Nutritional and Exercise Interventions for Cachexia in Chronic Diseases: A Systematic Review and Meta-analysis Limited to Cancer Cachexia - PubMed
5 hours ago
- #nutritional intervention
- #exercise therapy
- #cachexia
- Combined nutritional and exercise interventions for cachexia in chronic diseases were evaluated, focusing on cancer cachexia.
- Cachexia is characterized by weight loss and reduced muscle mass, often with inflammation, in chronic diseases like cancer and heart failure.
- The systematic review and meta-analysis found very low certainty evidence on the effectiveness of combined interventions, with no high-quality evidence supporting their benefits.
- Five studies involving cancer patients were included, showing uncertain impacts on mortality rates compared to control groups.
- Meta-analyses for other outcomes were not possible due to sparse and heterogeneous data.
- Twenty-two ongoing trials involving patients with cancer, chronic kidney disease, and AIDS were identified, with results pending.
- The review highlights the need for more rigorous, well-designed trials and the development of core outcome sets for future meta-analyses.
- Conflict of interest statements reveal various financial relationships between authors and pharmaceutical companies.