Liver transplantation in unresectable intrahepatic cholangiocarcinoma following neoadjuvant chemotherapy and SIRT - PubMed
5 hours ago
- #Neoadjuvant therapy
- #Intrahepatic cholangiocarcinoma
- #Liver transplantation
- Liver transplantation (LT) was evaluated for unresectable intrahepatic cholangiocarcinoma (iCCA) after neoadjuvant chemotherapy and selective internal radiation therapy (SIRT).
- 6 patients underwent LT between 2010-2024, with a median follow-up of 4.9 years.
- Five-year overall survival was 100%, while five-year progression-free survival was 44.4%.
- 3 patients experienced iCCA recurrence post-LT, but no deaths from tumor progression were reported.
- The study suggests LT may be reconsidered for highly selected iCCA patients with sustained disease control after neoadjuvant therapy.
- Prospective trials are needed to further evaluate this neoadjuvant combination approach.