The efficacy and safety of MSCs in GVHD prevention and the treatment of SR-aGVHD: a systematic review and meta-analysis of randomized controlled trials - PubMed
5 days ago
- #GVHD
- #MSCs
- #meta-analysis
- MSCs significantly reduce the incidence of aGVHD and cGVHD.
- MSC therapy improves response rates in steroid-refractory aGVHD (SR-aGVHD).
- Optimal prophylactic outcomes were observed with a dose range of 1 × 10^6 to < 4 × 10^6 cells/kg.
- MSC infusion resulted in higher remission rates for severe SR-aGVHD compared to conventional treatments.
- The study is based on a meta-analysis of 15 randomized controlled trials (RCTs).