TREM-1-dependent macrophage infiltration mediates visceral hypersensitivity via vlPAG GABAergic neuron activation in a mouse model of inflammatory bowel disease - PubMed
6 hours ago
- #visceral pain
- #GABAergic neurons
- #TREM-1
- TREM-1-dependent macrophage infiltration into the periaqueductal gray (PAG) mediates visceral hypersensitivity in a mouse model of inflammatory bowel disease (IBD).
- Peripheral monocytes/macrophages (Mo/MΦ) infiltrating the PAG enhance ventrolateral PAG (vlPAG) GABAergic neuronal activity, contributing to visceral pain during acute colitis and persisting into remission.
- Microinjection of Ly6C+ monocytes into the vlPAG activates GABAergic neurons and increases visceral pain sensitivity.
- Pharmacological inhibition or genetic knockout of TREM-1 reduces Mo/MΦ infiltration, decreases vlPAG GABAergic neuronal activity, and alleviates visceral pain.
- Findings suggest TREM-1 as a therapeutic target for acute intestinal inflammation and chronic visceral pain in IBD.