Understanding Pulmonary Fibrosis in Pediatric Interstitial Lung Disease: A Comprehensive Analysis - PubMed
7 hours ago
- #pediatric interstitial lung disease
- #respiratory disorders
- #pulmonary fibrosis
- Pulmonary fibrosis (PF) is a significant complication in childhood interstitial lung diseases (chILD), linked to higher mortality and morbidity.
- The study analyzed 404 pediatric patients from 25 centers, with a median age of 137 months, to assess PF prevalence and characteristics.
- Radiologic findings showed reticular abnormalities in 34.9% of patients, cystic abnormalities in 21%, and honeycombing in 2.5%.
- Patients with PF findings were older and had lower weight z-scores, but no significant differences in pulmonary function tests (PFTs) except for lower DLCO%.
- DPLD-A disorders (e.g., surfactant dysfunction) had a higher prevalence of PF compared to DPLD-B disorders.
- Early detection of PF is crucial, especially in older children with lower DLCO scores and DPLD-A disorders.