Mitochondrial transplant activates Ca2+/TFAP2A to promote hDPSCs-mediated dentin-pulp regeneration - PubMed
4 hours ago
- #mitochondrial transplant
- #tissue regeneration
- #stem cells
- Mitochondrial transplantation enhances viability and odontogenic differentiation of human dental pulp stem cells (hDPSCs).
- Optimal mitochondrial transplant rate observed at a recipient-to-donor cell ratio of 1:3.
- Mito-hDPSCs show increased formation of dentin-pulp-like tissue in vivo.
- Ca2+ signaling and TFAP2A identified as key factors in odontogenic differentiation.
- Mitochondrial transplantation upregulates TFAP2A expression via increased intracellular Ca2+ concentration.
- Study suggests mitochondrial transplantation promotes dentin-pulp complex regeneration through Ca2+/TFAP2A signaling.