Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE-/- mice via regulating estrogen receptor α - PubMed
5 hours ago
- #estrogen receptor alpha
- #atherosclerosis
- #postmenopausal health
- PQS reduces atherosclerosis in ovariectomized ApoE-/- mice, mimicking postmenopausal conditions.
- The reduction occurs by decreasing inflammation and apoptosis of aortic endothelial cells.
- PQS targets estrogen receptor α (ERα), influencing ERα/PI3K/Akt and ERα/MEK/ERK1/2 pathways.
- ERα inhibitor counteracts PQS benefits, while ERα activator enhances them, confirming ERα's role.
- The findings suggest PQS as a potential therapeutic target for postmenopausal atherosclerosis.