Glycosylation as a dynamic regulator of RLR and cGAS-STING innate immune signalling pathways - PubMed
5 hours ago
- #glycosylation
- #innate immunity
- #immune signaling
- Glycosylation regulates RLR and cGAS-STING innate immune pathways.
- N-glycosylation in ER-Golgi is crucial for STING stability and signaling.
- Cytosolic O-GlcNAcylation modulates RLR-cGAS pathways by affecting MAVS aggregation and IRF3/NF-κB activation.
- Glycosylation interacts with ubiquitination and phosphorylation, influencing immune responses.
- Metabolic regulation of UDP-GlcNAc flux and pathogen/tumor-driven glycosylation changes are discussed.
- Glycosylation enzymes are potential targets for immunomodulation.