Molecular characteristics of apolipoprotein M and its biological functions in kidney diseases - PubMed
6 hours ago
- #Apolipoprotein M
- #Kidney Disease
- #Sphingosine-1-phosphate
- Apolipoprotein M (apoM) is an apolipoprotein mainly associated with high-density lipoprotein (HDL) and is produced in the liver and kidneys.
- ApoM binds to sphingosine-1-phosphate (S1P) to form the apoM-S1P complex, which influences various physiological and pathological functions in the body.
- Though primarily studied in cardiovascular contexts like atherosclerosis, recent research highlights apoM's significant involvement in kidney diseases.
- The review explores the roles of apoM and the apoM-S1P axis in conditions such as chronic kidney disease, diabetic nephropathy, acute kidney injury, glomerular diseases, and renal clear cell carcinoma.
- These insights could lead to new diagnostic and therapeutic strategies for kidney diseases.