Mendelian Randomization Reveals Genetic Associations Between Immune Traits and Urethral Stricture - PubMed
12 hours ago
- #immune traits
- #urethral stricture
- #Mendelian randomization
- Study used Mendelian randomization (MR) to explore genetic associations between immune traits and urethral stricture.
- Analyzed 731 immunological characteristics in a sample size of 341,285 for urethral stricture.
- Identified 37 immune phenotypes with suggestive causal relationships to urethral stricture, including various B cell, dendritic cell, myeloid cell, monocyte, TBNK, Treg, and T cell subtypes.
- Main method was inverse-variance weighted (IVW), supplemented by MR-Egger and weighted median (WM).
- Sensitivity analyses confirmed robustness of results with no heterogeneity or pleiotropy detected.
- Findings suggest potential causal links between immune cells and urethral stricture, which could influence future treatment approaches.