Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle - PubMed
6 hours ago
- #exercise performance
- #type 2 diabetes
- #AMPK
- AMPK α2 T172 activation is crucial for exercise performance and energy transduction in skeletal muscle.
- Nonactivatable Ampkα2 knock-in mice (T172A) showed increased fat-to-lean mass and impaired endurance exercise capacity.
- AMPK α2 T172 activation influences glycolytic and oxidative metabolism, mitochondrial respiration, and contractile function.
- Proteomic changes in Ampkα2 T172A mice resemble those in type 2 diabetes patients, suggesting therapeutic potential.
- The study used CRISPR-Cas9 to create knock-in mice, avoiding disruptions in protein stoichiometry seen in previous genetic interventions.