Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway - PubMed
4 days ago
- #Rheumatoid Arthritis
- #NLRP3 Inflammasome
- #Macrophage Polarization
- Blockade of KCa3.1 (KCNN4) reduces rheumatoid arthritis (RA) symptoms in mouse models (CIA and CAIA).
- KCa3.1 inhibition suppresses M1 macrophage polarization, reducing inflammatory markers like iNOS, TNF-α, and IL-6.
- KCa3.1 promotes NLRP3 inflammasome activation, which drives macrophage inflammatory responses in RA.
- TRPM7 enhances KCa3.1-mediated NLRP3 inflammasome activation.
- Targeting KCa3.1 could be a therapeutic strategy to rebalance macrophage phenotypes and halt RA progression.