Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells - PubMed
6 hours ago
- #genomic instability
- #telomere
- #senescence
- Telomere shortening in telomerase-negative cells triggers replicative senescence and genomic instability.
- A single shortest telomere below a threshold length is necessary and sufficient to trigger replicative senescence.
- Genomic instability arises predominantly in cis to the shortest telomere, leading to non-reciprocal translocations.
- Pol32-dependent non-reciprocal translocations result in re-elongation of the shortest telomere, allowing transient escape from senescence.
- The study uses Saccharomyces cerevisiae to model telomere dynamics and senescence mechanisms.