Engineered Pericyte-Targeted Extracellular Vesicles Protect Against Hypoperfusion-Induced Cognitive Impairment and Vascular Demyelination - PubMed
4 hours ago
- #pericyte targeting
- #extracellular vesicles
- #vascular cognitive impairment
- Engineered cNGR-peptide extracellular vesicles (EVs) target pericytes through CD13 binding.
- In a mouse model of chronic cerebral hypoperfusion (BCAS), cNGR-EVs protect pericyte function, reduce BBB leakage, and prevent demyelination.
- Treatment with cNGR-EVs improves cognitive performance and normalizes transcriptional changes in pericytes and glial cells.
- This approach highlights pericytes as a therapeutic target for early vascular cognitive impairment (VCI).