Safety and efficacy of intensive task-specific training in people with recent spinal cord injury: a phase 3, pragmatic, randomised, assessor-blinded, superiority trial - PubMed
10 hours ago
- #rehabilitation
- #spinal cord injury
- #clinical trial
- Study aimed to determine if 10 weeks of intensive task-specific training plus strength training improves recovery in recent spinal cord injury (SCI) patients.
- Phase 3 randomized controlled trial conducted across 15 hospitals in multiple countries.
- 220 participants were randomly assigned to either usual care (control) or usual care plus 12 hours per week of intensive training (intervention).
- Primary outcome was Total Motor Score of the International Standards for the Neurological Classification of SCI at 10 weeks.
- No significant difference in Total Motor Scores between the intervention and control groups (mean difference 0.93, p=0.48).
- Four serious adverse events reported, including two deaths in the intervention group.
- Conclusion: Intensive task-specific training did not provide significant benefits over usual inpatient rehabilitation care.
- Funding provided by New South Wales Ministry of Health, University of Sydney, and Wings for Life.