Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy - PubMed
5 hours ago
- #Myocardial Ischemia-Reperfusion Injury
- #PANoptosis
- #Nanoparticles
- Prussian blue nanoparticles (PB) target PANoptosome components to inhibit PANoptosis in myocardial ischemia-reperfusion injury (MIRI).
- Platelet membrane-coated PB nanoparticles (PB@PM) enhance cardiac targeting and improve MIRI outcomes.
- PB@PM disrupts PANoptosome assembly, scavenges reactive oxygen species, and restores immune-inflammatory homeostasis.
- The study integrates multi-omics approaches to explore PANoptosis in cardiovascular diseases.
- PB nanoparticles offer a promising nanotherapeutic strategy for MIRI treatment.