Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination - PubMed
5 hours ago
- #Microglia
- #Remyelination
- #Aging
- The Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination by inhibiting progressive CD22 upregulation.
- Bhlhe41 is microglia-enriched, negatively autoregulated, and inhibited by Aurka loss; its deficiency in young mice leads to aging-like microglial issues and remyelination impairment.
- Ectopic Bhlhe41 expression counteracts phagocytic deficits and CD22 upregulation in Aurka-deficient microglia, while CD22 blockade restores phagocytic function and remyelination in Bhlhe41-deficient mice.
- A conserved pattern of CD22 upregulation is found in human PCDH9high microglia subsets with BHLHE41 downregulation, offering insights into therapeutic strategies for aging-related neurodegeneration.