Identification and characterization of a lipopolysaccharide binding, anti-inflammatory protein from Parabacteroides distasonis - PubMed
5 hours ago
- #Anti-inflammatory protein
- #Lipopolysaccharide binding
- #Parabacteroides distasonis
- A lipopolysaccharide (LPS) binding anti-inflammatory protein, A6LA28, was identified in Parabacteroides distasonis.
- A6LA28 suppresses LPS-induced cytokine production (IL-8, IL-6, TNFα) in cell models and blocks LPS binding to cells.
- The C-terminal region of A6LA28 is critical for its function, likely forming an LPS binding pocket, while the N-terminal deletion has minimal impact.
- This protein may inhibit TLR4-mediated inflammation by binding to LPS, though its native role in P. distasonis and in vivo effects require further study.