Genetically Predicted Use of Common Analgesics and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study - PubMed
4 hours ago
- #Analgesics and COPD
- #Mendelian Randomization
- #Pharmacogenetics
- Mendelian randomization study examines causal links between genetically predicted use of paracetamol, aspirin, ibuprofen, and COPD.
- Paracetamol use is significantly associated with increased COPD risk (OR 6.00, 95% CI 2.43-14.82).
- Aspirin use is associated with decreased COPD risk (OR 0.19, 95% CI 0.05-0.71).
- Ibuprofen use shows no significant association with COPD risk.
- Reverse analysis finds no causal effect of COPD genetic liability on analgesic use.
- Sensitivity analyses including MR-Egger and MR-PRESSO support robust results without pleiotropy.
- Findings suggest analgesic choice may impact COPD risk, requiring further clinical study.