Multiomics Integration Prioritizes ZFP36L1 as a Candidate Susceptibility Gene Associated With Inflammatory and Angiogenic Pathways in Diabetic Retinopathy - PubMed
5 hours ago
- #Diabetic Retinopathy
- #ZFP36L1
- #Multiomics
- Multiomics analysis identifies ZFP36L1 as a novel susceptibility gene for diabetic retinopathy (DR).
- Mendelian randomization shows ZFP36L1 expression in blood is genetically linked to increased DR risk.
- ZFP36L1 correlates with inflammatory markers (TNF-α, IL-6) and immune pathways, including NF-κB and TGF-β signaling.
- An unexpected positive correlation between ZFP36L1 and VEGF is observed in diabetic conditions.
- Retinal single-cell RNA sequencing and pathway analyses suggest ZFP36L1's role in DR-related inflammation and angiogenesis.