Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women - PubMed
2 days ago
- #Alzheimer's disease
- #biomarkers
- #cognitive decline
- Plasma phosphorylated tau 217 (p-tau217) is associated with incident mild cognitive impairment (MCI) and dementia in older women.
- The study involved 2766 women aged 65-79, with 1311 developing MCI or dementia over 25 years.
- Higher p-tau217 levels were linked to increased risk of MCI or dementia (HR: 2.43 per 1-SD increase).
- Associations were stronger in women over 70, APOE ε4 carriers, and White women compared to Black women.
- P-tau217 was not associated with MCI in Black women, but age and p-tau217 combined predicted risk similarly in White and Black women.
- Hormone therapy (estrogen plus progestin) increased the association between p-tau217 and dementia (HR: 4.18 vs. 3.07 for placebo).
- The findings suggest p-tau217 is a long-term predictor of cognitive decline, with variations by age, race, APOE ε4 status, and hormone therapy use.