Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis - PubMed
5 hours ago
- #sucralose
- #gut microbiota
- #ovarian aging
- Long-term sucralose exposure accelerates ovarian aging.
- Sucralose induces gut microbiota dysbiosis and disrupts intestinal tight junctions.
- Increased LPS production from gram-negative bacteria enters systemic circulation.
- LPS binds to TLR4 in ovarian granulosa cells, activating NF-κB pathway.
- NF-κB activation leads to inflammation via p65 subunit translocation.
- Baicalin methyl ester may mitigate inflammation by inhibiting TLR4/NF-κB pathway.