High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANE
5 hours ago
- #mortality risk
- #ageing population
- #inflammatory markers
- The study examined HDL-related inflammatory markers (NHR, LHR, MHR, PHR) and their links to mortality in adults aged 60+ from NHANES data.
- Higher Neutrophil/HDL Ratio (NHR) was linearly associated with increased all-cause and cardiovascular mortality, with the highest tertile showing 29% higher all-cause and 70% higher CVD mortality.
- Higher Lymphocyte/HDL Ratio (LHR) had a non-linear inverse association, linked to lower mortality (21% lower all-cause and 31% lower CVD in the highest tertile).
- Monocyte/HDL Ratio (MHR) and Platelet/HDL Ratio (PHR) showed no significant associations with mortality outcomes.
- The findings suggest NHR may be a useful inflammatory-lipid marker for assessing mortality risk in ageing populations.