MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes - PubMed
5 hours ago
- #Efferocytosis
- #Macrophage
- #Cardiomyopathy
- MARCH2 expression is reduced in cardiac macrophages from doxorubicin-induced cardiomyopathy (DiCM) models and human patients.
- MARCH2 stabilizes NR1H2 via K27-linked polyubiquitination, enhancing the efferocytosis receptor MERTK for apoptotic cardiomyocyte clearance.
- Loss of MARCH2 or NR1H2 in macrophages worsens DiCM, impairs efferocytosis, and increases inflammation.
- Pharmacological activation of NR1H2 attenuates DiCM progression, highlighting therapeutic potential.