Elevated serum trimethylamine N-oxide (TMAO) and trimethyllysine in patients with amyotrophic lateral sclerosis (ALS): An exploratory case-control study - PubMed
4 days ago
- #TMAO
- #ALS
- #metabolomics
- Elevated serum levels of TMAO and TML were found in ALS patients compared to healthy controls.
- TMAO levels in ALS patients showed a wide range (2.4-125.0 µmol/L), indicating inter-individual variability.
- No significant differences were observed in levels of choline, carnitine, betaine, ergothioneine, and γ-butyrobetaine between ALS patients and controls.
- Most ALS patients were on acetyl-L-carnitine (ALCAR) supplementation, which might influence the observed metabolite profiles.
- The study highlights the need for larger, well-controlled studies to understand the role of trimethylammonium-containing compounds in ALS.