Deep multi-omics profiling reveals three molecular subtypes of chronic obstructive pulmonary disease in a unique biomass-exposed Chinese population - PubMed
5 days ago
- #biomass-exposure
- #COPD
- #multi-omics
- Deep multi-omics profiling identifies three molecular subtypes of COPD in a unique Chinese population exposed to biomass fuels.
- The study involved 159 COPD patients, integrating radiomics, metabolomics, microbiomics, and genomics data.
- Three distinct molecular subtypes were identified: 'stable state' (SS), 'restrained state' (RS), and 'crumbly state' (CS).
- SS subtype shows mild airflow limitation and potential eosinophilic inflammation.
- RS subtype exhibits extensive pulmonary damage but mild clinical symptoms.
- CS subtype is linked to disturbed microbial interaction, high triethanolamine, coal dust exposure, and nicotine dependence.
- The findings enhance understanding of COPD heterogeneity in understudied populations.