Reduction in hippocampal cholinergic neurostimulating peptide enhances memory impairment in AppNL-G-F KI mice - PubMed
4 hours ago
- #Alzheimer's disease
- #cholinergic system
- #mouse model
- Reduced levels of hippocampal cholinergic neurostimulating peptide (HCNP) worsen memory impairment in AppNL-G-F knock-in mice.
- The study used a mouse model combining HCNP precursor protein conditional knockout with amyloid-beta precursor gene mutation.
- Decreased HCNP led to impaired theta power and long-term potentiation without additional pathological or inflammatory changes.
- Key cholinergic markers like NR2A, ChAT, and VAChT were reduced in the hippocampus and medial septal nucleus.
- Cholinergic dysfunction in HCNP-deficient mice exacerbates cognitive deficits in Alzheimer's disease model mice.
- This mouse model is useful for studying interactions between cholinergic dysfunction and amyloid pathology in Alzheimer's.