Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development - PubMed
4 hours ago
- #Osteoarthritis
- #Macrophage
- #Piezo1
- Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis (OA) development.
- Piezo1 expression is upregulated in synovial macrophages from OA joints compared to healthy joints.
- Macrophage-specific deletion of Piezo1 alleviates OA symptoms and promotes chondrocyte anabolism.
- Piezo1 facilitates M1 macrophage polarization by activating the NLRP3 inflammasome via the DRP1-cGAS-STING pathway.
- Targeted delivery of Si-Piezo1 nanoparticles suppresses Piezo1 expression, reduces M1 macrophages, and alleviates OA progression.
- Mannose-modified liposomes carrying Si-Piezo1 provide a promising therapeutic strategy for OA treatment.