Effect of MYCN Amplification on Tumor Response and Recurrence in Patients With Stage IV Neuroblastoma - PubMed
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- #tumor recurrence
- #MYCN amplification
- #neuroblastoma
- MYCN amplification (MYCN-A) is a significant prognostic marker in stage IV neuroblastoma, affecting overall survival and recurrence rates.
- Patients with MYCN-A achieved complete remission faster but had a higher probability of recurrence compared to those without MYCN-A.
- MYCN-A was associated with lower SIOPEN scores on MIBG scintigraphy at diagnosis and after induction treatment.
- The study included 164 patients with metastatic high-risk neuroblastoma, 30% of whom had MYCN-A.
- MYCN-A was linked to a higher cumulative incidence of recurrence both from diagnosis and after induction treatment.