Aerobic Exercise Stabilizes HIF1α through P4HA1 to Activate Nrf2/GPX4 Inhibiting Ferroptosis and Attenuating Diabetic Cardiomyopathy - PubMed
5 hours ago
- #Diabetic Cardiomyopathy
- #Aerobic Exercise
- #Ferroptosis
- Aerobic exercise helps protect against diabetic cardiomyopathy (DCM) by inhibiting ferroptosis.
- DCM is linked to ferroptosis, characterized by mitochondrial changes, lipid peroxides, and increased reactive oxygen species.
- Exercise stabilizes HIF1α by activating P4HA1, reducing its ubiquitination and degradation.
- Stabilized HIF1α activates the Nrf2/GPX4 pathway, which inhibits ferroptosis and reduces oxidative stress.
- The study used in vitro cardiomyocytes and a DCM rat model to validate these mechanisms.