A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer - PubMed
5 hours ago
- #Therapeutic Vulnerabilities
- #Extrachromosomal DNA
- #Cancer Hallmarks
- Extrachromosomal DNA (ecDNA) can drive aggressive cancers by causing rapid genome change and therapy resistance.
- ecDNA untethers oncogenic elements from chromosomes, bypassing Mendelian inheritance and leading to genomic chaos and accelerated cancer evolution.
- ecDNA biology presents non-traditional therapeutic vulnerabilities, distinct from conventional mutation-targeting approaches.
- A holistic view integrates ecDNA into the Hallmarks of Cancer framework to understand cancer progression and guide future treatments.