Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice - PubMed
4 hours ago
- #microbiota
- #dietary interventions
- #feeding behavior
- Early-life high-fat/high-sugar (HFHS) diet causes persistent, sex-specific feeding behavior alterations in adult mice.
- HFHS diet reduces hypothalamic cells expressing feeding-related markers (POMC, GHSR, PNOC, NOD2) in adult mice.
- Females show reduced LEPR+ cells and disrupted arginine/tryptophan metabolism; males exhibit impaired peptidoglycan sensing and steroid metabolism.
- Microbiota interventions (FOS + GOS or Bifidobacterium longum APC1472) restore feeding behavior via distinct mechanisms.
- FOS + GOS induces microbiome shifts and gut-brain pathway restoration; B. longum APC1472 shows greater behavioral restoration with minimal microbiome changes.
- Study highlights sex-specific vulnerabilities and therapeutic potential of microbiota-based interventions post early-life unhealthy diets.