Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic - PubMed
5 hours ago
- #adipogenesis
- #fibro-adipogenic progenitors
- #spinal muscular atrophy
- Fibro-adipogenic progenitor cells (FAPs) in a mouse model of spinal muscular atrophy (SMA) show intrinsic adipogenic bias, contributing to pathological fat deposition in muscles.
- Proteomic profiling and RNA sequencing reveal early adipogenic priming, increased lipid biosynthesis, and dysregulated lipid metabolism in SMA FAPs.
- Reduced SMN activity enhances adipogenesis in FAPs, which can be normalized with Risdiplam or induced in control FAPs via SMN1 knockdown.