Long-term outcomes after proton therapy vs. intensity-modulated photon radiotherapy with concurrent chemotherapy for locally advanced non-small-cell lung cancer: post-hoc analysis of a prospective ran
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- #Proton Therapy
- #Radiation Oncology
- #Non-Small-Cell Lung Cancer
- Compared proton therapy (PSPT) and photon radiotherapy (IMRT) with chemotherapy for locally advanced non-small-cell lung cancer.
- No significant differences in grade ≥3 radiation pneumonitis (10.9% IMRT vs. 10.5% PSPT) or local failure between the two groups.
- Fewer radiation-related major adverse cardiac events with proton therapy (1 vs. 9 cases), potentially due to lower coronary artery doses.
- Esophageal toxicity rates were similar, with no significant differences observed between IMRT and PSPT.
- Tumor volume and radiation dose identified as key factors influencing survival outcomes.
- Long-term survival outcomes comparable to those reported in the RTOG 0617 trial.