GPR182 is a lipoprotein receptor for dietary fat absorption - PubMed
5 hours ago
- #Obesity
- #Lipoproteins
- #Metabolism
- GPR182 is identified as a lipoprotein receptor crucial for dietary fat absorption.
- GPR182 knockout mice show resistance to dietary-induced obesity and have increased high-density lipoproteins.
- Loss of GPR182 function leads to poor lipid absorption and delayed growth in mice.
- Mechanistically, GPR182 facilitates the entry of chylomicrons into the lacteal lumen of the small intestine.
- Blocking GPR182 with monoclonal antibodies protects against and treats obesity in mice.
- The study suggests GPR182 blockade as a potential therapeutic approach for obesity and related disorders.