Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis - PubMed
5 hours ago
- #aging
- #rejuvenation therapy
- #erythrocyte metabolism
- Aging-related tissue hypoxia is linked to decreased oxygen (O2) release capacity of red blood cells (RBCs).
- Reduction in 2,3-bisphosphoglyceric acid (2,3-BPG) due to decreased bisphosphoglycerate mutase (BPGM) activity is a key factor in RBC dysfunction with age.
- Erythroid inosine serves as an alternative fuel for RBCs when glucose metabolism is impaired during aging.
- Inosine supplementation alleviates age-related decline in BPGM activity, improving O2 delivery and tissue function.
- 2,3-BPG inhibits purine nucleoside phosphorylase (PNP) in RBCs; its decline with age increases PNP activity and inosine catabolism.
- Inosine is identified as a potential rejuvenating therapy for aging-related metabolic and functional declines in RBCs.