Integrative genomic and multi-omics analyses identify oxidative stress-related pathways and druggable targets for tinnitus - PubMed
3 days ago
- #multi-omics
- #tinnitus
- #oxidative stress
- Integrative genomic and multi-omics analyses link oxidative stress-related pathways to tinnitus, identifying ACADVL as a primary candidate gene.
- Multi-omics evidence shows increased ACADVL mRNA expression and VLCAD protein levels in tinnitus patients compared to healthy controls.
- ACADVL increases tinnitus risk by affecting immune and metabolic pathways, specifically suppressing CD25 on B cells and altering lipid ratios.
- Molecular docking identifies fenretinide as a potential repurposable therapeutic agent targeting oxidative stress-related mechanisms.
- The study establishes a framework for investigating tinnitus mechanisms and developing therapies through genetic, multi-omics, and experimental integration.