PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi-Omics - PubMed
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- #PM10
- #FNBP1
- #rheumatoid arthritis
- Air pollution (AP) is linked to rheumatoid arthritis (RA), but its molecular and immunological impact remains unclear.
- Global epidemiological analysis shows rising RA prevalence in over 95% of countries.
- Mendelian randomization indicates a positive correlation between PM10 exposure and RA risk.
- Machine learning identifies FNBP1 as a key air pollution-related gene (APRG), with decreasing expression in RA patients.
- PM10 exposure impairs NK cell differentiation and cytotoxicity by suppressing FNBP1, weakening immune surveillance and exacerbating inflammation.
- PM10 exposure aggravates inflammation and joint damage in a collagen-induced arthritis (CIA) model.
- PM10 likely impairs CD56dim NK cell cytotoxicity via FNBP1 modulation, proposing the 'PM10-FNBP1-NK cells' axis in RA development.