Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk - PubMed
a day ago
- #cardiometabolic-disease
- #sleep-disordered-breathing
- #hypoxia
- Sleep-disordered breathing (SDB) involves intermittent airway closure or narrowing due to mechanical obstruction or brainstem respiratory center dysregulation.
- SDB impacts cardiovascular and metabolic health through autonomic dysfunction, intrathoracic pressure changes, inflammation, sleep fragmentation, and oxidative stress.
- Mechanistic pathways of SDB affect vascular/myocardial dysfunction, hypertension, insulin sensitivity, lipid metabolism, and weight gain via gene expression and gut microbiome changes.
- Treatment for SDB improves symptoms and may reduce cardiometabolic disease risk, with options tailored to disease type and patient tolerance.
- Key mechanisms include hypoxia-inducible factor 1 (HIF-1) and microRNA alterations, linking SDB to systemic inflammation and metabolic dysregulation.