Use of Oral Metformin Therapy for Therapy-Induced Hyperglycemia in Pediatric Patients With Acute Lymphoblastic Leukemia - PubMed
5 hours ago
- #acute lymphoblastic leukemia
- #hyperglycemia
- #metformin
- Hyperglycemia in pediatric ALL patients is often induced by corticosteroids and asparaginase.
- Metformin is a promising alternative to insulin due to ease of use, lower hypoglycemia risk, and noninvasive administration.
- Study evaluated efficacy and safety of oral metformin in managing therapy-induced hyperglycemia (TIH) in pediatric ALL patients.
- Out of 281 ALL patients, 54 (19.2%) developed TIH, with a median age of 12 years.
- Metformin successfully controlled blood glucose in 73.4% of induction-phase patients, while 26.5% required insulin.
- During re-induction, seven patients needed dual therapy (metformin and insulin).
- Metformin was well-tolerated with no adverse effects warranting discontinuation.
- Glycemic management did not interfere with leukemia remission or treatment completion.
- Metformin proved to be a safe and effective first-line option for managing TIH in pediatric ALL.