TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma - PubMed
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- #TRIM21
- #ccRCC
- TRIM21-mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma (ccRCC).
- FBL, a nucleolar C-Myc target, is upregulated in ccRCC and associated with poor prognosis.
- FBL promotes ccRCC cell proliferation, migration, and tumor growth via PI3K/AKT pathway activation.
- TRIM21 acts as an E3 ubiquitin ligase, catalyzing K48-linked polyubiquitination of FBL, leading to its degradation.
- TRIM21 overexpression reduces FBL levels, inhibits PI3K/AKT signaling, and reverses oncogenic effects.
- TRIM21 is downregulated in ccRCC tissues and linked to unfavorable prognosis.
- The TRIM21-FBL axis provides potential therapeutic targets for ccRCC treatment.