SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury - PubMed
5 hours ago
- #Ischemia-reperfusion injury
- #SAA/FPR2 signaling
- #Liver transplantation
- Liver transplant injury exhibits selective pericentral vulnerability due to disproportionate hepatocyte injury and heightened macrophage crosstalk.
- Mechanistic findings reveal FOXO1-driven SAA secretion from pericentral hepatocytes recruits and activates FPR2+ macrophages, worsening zonal injury.
- Pharmacological inhibition of SAA with Amilo-5MER reduces macrophage accumulation, alleviates pericentral damage, and mitigates zonal disparities in injury.