ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition - PubMed
5 hours ago
- #TAS2R agonist
- #Obesity
- #Weight loss
- ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice.
- Combination with sitagliptin (DPP-4 inhibitor) enhances weight loss and metabolic benefits in mice.
- In clinical studies, ARD-101 reduced weight, hunger, and food cravings in adults with obesity.
- TAS2R agonism shows potential for treating hyperphagia in Prader-Willi syndrome and obesity.
- ARD-101 alters gut hormone levels, suggesting a gut-brain signaling mechanism.