Global reorganization of genome architecture at the transition to gametogenesis - PubMed
a day ago
- #epigenetics
- #genome_architecture
- #gametogenesis
- Global epigenetic resetting in gonadal primordial germ cells (PGCs) enables transition to gametogenesis and restores totipotency post-fertilization.
- Premeiotic gonadal germ cells exhibit distinct chromosome and genome architecture, including separation of chromosomes, peripheral centromere anchoring, and reduced interchromosome interactions.
- Remodeling of 3D genome architecture involves disruption of TADs, loss of detectable loops, and reduced active-active compartment interactions, correlating with decreased CCCTC-binding factor levels.
- PGC-like cells from embryonic stem cells do not replicate the chromatin organization of embryonic germ cells.
- Germline epigenetic reprogramming includes erasure of memory at the genome architectural level through profound 3D genome reorganization.