TMPRSS2-induced Golgi disruption restricts the incorporation of virus envelope glycoproteins into virions - PubMed
2 hours ago
- #TMPRSS2
- #viral infectivity
- #Golgi disruption
- TMPRSS2 reduces infectivity of SARS-CoV-2 and HIV-1 during viral production, with inhibition increasing infectious virion output.
- TMPRSS2 disrupts the trans-Golgi via ERK activation, phosphorylating Golgi stacking proteins, impairing spike incorporation and glycoprotein maturation.
- SARS-CoV-2 E protein counteracts TMPRSS2 to rescue spike incorporation, optimizing viral replication by regulating the Golgi system.