Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion - PubMed
2 days ago
- #metastasis
- #melanoma
- #nuclear envelope
- Metastatic melanoma cells exhibit increased nuclear envelope (NE) fragility during confined migration, leading to NE rupture and DNA damage.
- Lamin B receptor (LBR) upregulation is linked to melanoma progression and NE fragility, promoting nuclear deformability and instability.
- LBR's sterol reductase activity is essential for NE fragility, contributing to nuclear membrane blebs and rupture.
- Higher LBR levels correlate with increased metastatic invasion, NE fragility, and reduced patient survival in melanoma.
- The study suggests LBR-driven nuclear instability as a mechanism for genetic heterogeneity in aggressive melanomas.