Interactions between neutrophil extracellular traps and macrophages: the key to inflammatory diseases - PubMed
5 hours ago
- #cellular communication
- #inflammatory diseases
- #immune response
- Interactions between neutrophil extracellular traps (NETs) and macrophages are crucial in inflammatory diseases.
- NETs influence macrophage polarization and function via DNA, histones, granule proteins, and signaling pathways.
- Macrophages affect NETs formation and clearance through cytokines and proteases.
- This bidirectional interaction creates a positive feedback loop in diseases like autoimmune disorders, cardiovascular diseases, and tumors.
- Understanding NETs-macrophage mechanisms could lead to new targeted therapies for inflammatory diseases.